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A CLINICIANS GUIDE TO SPERM DNA AND CHROMATIN DAMAGE

Armand Agarwal Ashok Zini

Oprawa:
MIĘKKA

Wydawca:
Springer International Publishing

ISBN:
9783030101169

1 528,75 PLN
Wysyłamy w 28 dni

Opis produktu

This comprehensive uptodate text which brings together the key practical elements of the rapidly evolving field of sperm DNA and chromatin abnormalities is divided thematically into five main sections. Part Idiscusseshuman sperm chromatin structure and nuclear architecture while part II presents laboratory evaluation of sperm DNA damage including SCSA SCD TUNEL and Comet assays and cytochemical tests. Biological and clinical factors in the etiology of sperm DNA damage are discussed in part III including oxidative stress abortive apoptosis cancer and environmental and lifestyle factors. Part IV presentsclinical studies on the utility of sperm DNA damage tests both with natural and ARTassisted pregnancies and debates the clinical utility of such tests.Finally part V discusses currenttreatment options such as antioxidant therapy varicocelectomybadvanced sperm processing techniques and theuse of testicular sperm./b/ We are now beginning to better understand the unique organization of the sperm chromatin as well as the nature and etiology of sperm DNA damage. Written and edited by worldwide experts in andrologyA Clinicians Guide to Sperm DNA and Chromatin Damage/is an excellent resource for reproductive medicine and REI specialists urologists reproductive biologists and any professional working with the infertileSperm Chromatin: An Overview.Sperm Nucleoproteins (Histones and Protamines).Sperm Nuclear Architecture.Sperm Chromatin Structure Assay (SCSA): Evolution from Origin to Clinical Utility.TUNEL Assay.TUNEL Assay by Bench Top Flow Cytometer in Clinical Laboratories.The Comet Assay.Sperm Chromatin Dispersion (SCD) Assay.Cytochemical Tests of Sperm Chromatin Maturity.Is There an Optimal Sperm DNA Test?.Oxidative Stress.Apoptosis in Ejaculated Spermatozoa and in the Normal and Pathological Testes: Abortive Apoptosis and Sperm Chromatin Damage.Defective Spermatogenesis and Sperm DNA Damage.Sperm Chromatin and Lifestyle Factors.Cancer and Sperm DNA Damage.Sperm Chromatin and Environmental Factors.Sperm DNA Damage and Oocyte Repair Capability.Experimental Studies on Sperm DNA Fragmentation and Reproductive Outcomes.Sperm DNA and Natural Pregnancy.Sperm DNA and ART (IUI IVF ICSI) Pregnancy.Sperm DNA and Pregnancy Loss after IVF and ICSI.Sperm DNA Tests are Clinically Useful: Pro.Sperm DNA Tests Are Clinically Useful: CON.Antioxidant Therapy.Varicocelectomy.Physiological IntraCytoplasmic Sperm Insemination Based on Hyaluronic Acid Binding Ability.Advanced Sperm Processing / Selection Techniques.Use of Testicular Sperm for ICSI: Pro.Debate on the Use of Testicular Sperm for ICSI: Con.Strategies to Diminish DNA Damage in Sperm Samples used for ART.Sperm DNA Testing: Where Do We Go from Here?bArmand Zini MD FRCSC Professor Department of Surgery Division of Urology St. Marys Hospital Center Montreal Quębec Canada// Ashok Agarwal PhD HCLD Professor Lerner College of Medicine of Case West

Wymiary: 1273 gr 155 mm 235 mm

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