WAR IN THE BODY

Opis produktu

In the relatively few decades since the introduction of HIV into the human population variants of the virus have diverged to such an extent that were the discussion about something other than viruses said variants could easily be classified as differentspecies. This book will consider these evolutionary variations as well as the different and at times opposing theories attempting to explain them. It will compare and contrast the ways in which the immune system and drugs affect the viruss evolution and the implications of these for vaccine development. The issue will be explored and explained through ecological genetics which postulatesthatall living organisms have besides rivals enemies. This is divergent from the more traditional school of population genetics which emphasizes that evolution occurs among rival species (or variants thereof) that competefor niches or resources in a fixed unreactive environment. Both models will be formulatedusing mathematical models which will be included in the book. Finally it will consider the possibilities for designing a vaccine that blocks HIV from escaping thThis book surveys the wide evolutionary variations of HIV and the different sometimes opposing theories which try to explain them. It compares ways that drugs anbd the immune system affect the viruss evolution and the implications for vaccThe HIV Infection model. The CTL Model. Simulating an HIV Infection In Vivo. The Escape Formula. Early and Late Escapes. Understanding Escape. More Topics about Escape from Immune Control. HIVs Cloaking Device: The Fascinating Story of Nef. Retroviral Sex and Escape. The Ne Business Again and a Proposed Experiment. Can a Tcell Vaccine Block Escape?. The STEP Trial and the Future of Tcell Vaccines. Short Tutorial on Dynamical Models. Deterministic Modeling: A Cautionary Example. The Infection Model Defined. The CTL Model Defined. On Simulation Techniques. Derivation of the Escape Formula. Statistics of the Mutant Lineage in Classical Genetics. Extinction Probabilities with Extra Poisson Variation. Computing the Boundaries. Coexistence or Replacement?. The NefDeletion Threshold Formulas. ModelingFrom the reviews:/Provide a critical overview of the mathematical modeling performed so far to understand HIV immunity and escape and advance an innovative alternative approach for stochastic simulation. War in the Body is not a howto guide tutorial or cookbook but a research monograph with thought exercises to cultivate problemsolving skills and foster developing plausible stable numerical simulations.Ł (Complexity MarchDr. Yang is a well known TCell and HIV expert at UCLA. Dr. Wick is recently retired. His last position was Senior Scientist in the Infectious Diseases Division of the Fred Hutchison Center in Seattle where he worked on immune response to HExplores the rapid and profound evolution of the HIV virus/Considers the divergent viewpoints on why and how the virus evolves/Addresses the ramific

Wymiary: 4861 gr 155 mm 235 mm