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ASSAY OF CALCIUM-REGULATING HORMONES

Bikle

Oprawa:
MIĘKKA

Wydawca:
Springer New York

ISBN:
9781461255550

438,86 PLN
Wysyłamy w 28 dni

Opis produktu

The ability to measure accurately the hormones regulating calcium homeosta sis is the fundamental first step toward understanding the roles these hormones play in health and disease. Techniques for such measurements have only been available for the past 10 years or so and remain in a state of rapid development. Sensitive parathyroid hormone (PTH) radioimmunoassays appeared in the early 1970s and with them came a whole new appreciation for the prevalence and implications of hyperparathyroidism primary or secondary in the popu lation. The calcitonin (CT) radioimmunoassay came later and achieved rapid success in the. diagnosis of a previously poorly understood cancer medullary carcinoma of the thyroid frequently associated with the familial multiple endo crine neoplasia type 2 syndromes (a and b). As the sensitivity of the calcitonin radioimmunoassay has improved our understanding of the role of calcitonin in normal physiological processes has increased. The knowledge that vitamin D must be metabolized to produce its biologic effects is only 15 years old. This has had profound implications in our understanding of a variety of metabolic bone kidney and gastrointestinal diseases. Assays to measure the major cir culating form of vitamin D 25hydroxyvitamin D were described 10 years ago. Assays for the other metabolites in particular 125dihydroxyvitamin D were described even more recently. As of today we know of many vitamin D metabolites and have developed the techniques to measure most of them: how ever many questions remain concerning their phyWithThe ability to measure accurately the hormones regulating calcium homeosta sis is the fundamental first step toward understanding the roles these hormones play in health and disease. Techniques for such measurements have only been available for the past 10 years or so and remain in a state of rapid development. Sensitive parathyroid hormone (PTH) radioimmunoassays appeared in the early 1970s and with them came a whole new appreciation for the prevalence and implications of hyperparathyroidism primary or secondary in the popu lation. The calcitonin (CT) radioimmunoassay came later and achieved rapid success in the. diagnosis of a previously poorly understood cancer medullary carcinoma of the thyroid frequently associated with the familial multiple endo crine neoplasia type 2 syndromes (a and b). As the sensitivity of the calcitonin radioimmunoassay has improved our understanding of the role of calcitonin in normal physiological processes has increased. The knowledge that vitamin D must be metabolized to produce its biologic effects is only 15 years old. This has had profound implications in our understanding of a variety of metabolic bone kidney and gastrointestinal diseases. Assays to measure the major cir culating form of vitamin D 25hydroxyvitamin D were described 10 years ago. Assays for the other metabolites in particular 125dihydroxyvitamin D were described even more recently. As of to

Wymiary: 441 gr 155 mm 235 mm

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